He was also cast as Sheriff Bronson Stone in the Cartoon Network series Scooby-Doo! Mystery Incorporated, and appeared as Bowser in a video by CollegeHumor, "The Roast of Mario". On November 8, 2009, he appeared as the Wild West character Cal Johnson on Seth & Alex’s (Almost Live) Comedy Show, hosted by Seth MacFarlane and Alex Borstein on Fox. the Pros tournament in 2005, winning the tournament and the $50,000 grand prize. Warburton appeared on GSN’s Poker Royale Celebrities vs. Tate on the Comedy Central animated series Moonbeam City in October 2015.
He was also the voice of Commander Blaine H. In video games, he voiced Lok in the Tak and the Power of Juju video game series and has also reprised the role again in the television series of the same name, as well as Flynn in the Skylanders series. He recorded voices for the computer-animated feature films Hoodwinked, Chicken Little, Bee Movie, Open Season. Warburton was also cast in The Venture Bros., where he voices Brock Samson, and voices Joe Swanson on Fox’s Family Guy and Detective Cash in The Batman. He voiced Steve Barkin in the Disney Channel show Kim Possible.
Warburton reprised his role as Kronk for the direct-to-video sequel Kronk's New Groove, and the subsequent TV series The Emperor's New School. Spade and Warburton reunited for the CBS sitcom Rules of Engagement, which aired from 2007 to 2013, and Joe Dirt 2: Beautiful Loser in 2015. Warburton has provided voices for several animated films and TV programs, including a lead character in Game Over, Buzz Lightyear the Little Green Men in Buzz Lightyear of Star Command and Kronk in The Emperor's New Groove, with David Spade, Eartha Kitt, and John Goodman. He also played Jeff Bingham in Rules of Engagement, and Rip Riley in the FX series Archer. He played Nick Sharp in 8 Simple Rules and in 2003, joined the cast of Less Than Perfect as anchorman Jeb Denton. He has repeatedly criticized FOX's mismanagement of the series after its cancellation, stating that the network "apparently didn't have a clue." In 2016 he was a producer for the Amazon streaming version of the series. Warburton played the title role in FOX's short-lived series The Tick. He played Eric in the sitcom "Dave's World", and had a small role in the 2002 film Men in Black II as J's new partner, T. In the 1990s, he was known for his recurring role in Seinfeld as David Puddy, the on-again, off-again boyfriend of Elaine Benes. Warburton's acting roles often rely on his distinctive deep, booming voice and large physique.
He studied marine biology at Orange Coast College in Costa Mesa, California, but dropped out to pursue modeling and acting. He later attended Servite High School (in Anaheim, California), then transferred to Newport Harbor High School (in Newport Beach, California). He and his three sisters, Mary, Lara, and Megan, were raised in a "very religious" and "conservative" Catholic family in Huntington Beach, California, where he attended Saints Simon and Jude Catholic School. and Barbara Jeanne Gratz (an actress credited as Barbara Lord). Warburton is the son of orthopedic surgeon John Charles Warburton Jr.